The Epigenetic Story

Epigenetic targeted anti-cancer drugs: an unfolding story.

Boumber and Issa provide a useful review of the development of agents that target the epigenome—primarily DNA methyltransferase (DNMT) inhibitors and histone deacetylase (HDAC) inhibitors. The authors provide a summary of agents approved for clinical use: the DNMT inhibitors azacitidine (Vidaza) and decitabine (Dacogen), and the HDAC inhibitors vorinostat (Zolinza) and romidepsin (Istodax). In ...

Editor's Note/Man, the Story-Telling Animal

epigenetic modulations on the fetal hemoglobin induction

in recent years of experience fetal hemoglobin (hbf) induction considers as novel therapeutic approach for β-thalassemia and sickle cell in therapeutic approaches. several pharmacologic agents such as hydroxyurea, azacytidine, butyrate deriviates and immunomodulator drugs like pomalidomide and lnalidomide could able to up-regulate hbf level with different molecular and epigenetic paterns (1-4)....

The importance of epigenetic modifications in cancer progression

Epigenetics are dynamic and inherited changes in the genome that occur independently of DNA sequencing. This phenomenon requires coherent interaction with various enzymes and other molecular components. Abnormal epigenetic changes can lead to the onset of improper gene expression and the promotion of tumorigenesis. Because epigenetic changes are prone to external and reversible factors, they ar...

the archetype of mother: a never-ending story retold by poe

investigation the archetype of mother can help the reader to understand poes works, especially his fiction, better, if not fully. motivated by internal and external drives to get into the universe in its manifold form poe was impelled to art and, from various modes of art, to symbolism. how much was poe successful to produce works of art has been a matter of dispute among critics. however, ther...